Culinary plants, herbs and spices - A rich source of PPAR[gamma] ligands

Obesity and the related disorders, diabetes, hypertension and hyperlipidemia have reached epidemic proportions world-wide. The influence of 70 plants, herbs and spices on peroxisome proliferators-activated receptor (PPAR)[gamma] activation or antagonism, a drug target for metabolic syndrome, was investigated. Approximately 50 different plant extracts bound PPAR[gamma] in competitive ligand binding assay, including pomegranate, apple, clove, cinnamon, thyme, green coffee, bilberry and bay leaves. Five plant extracts transactivated PPAR[gamma] in chimeric GAL4-PPAR[gamma]-LBD system: nutmeg, licorice, black pepper, holy basil and sage. Interestingly, nearly all plant extracts antagonized rosiglitazone-mediated coactivator recruitment in time resolved fluorescence resonance energy transfer coactivator assay. The five transactivating extracts may function as selective PPAR[gamma] modulators (SPPAR[gamma]Ms), and the other extracts seem to be moderate antagonists or undetectable/weak SPPAR[gamma]Ms. As SPPAR[gamma]Ms improve insulin resistance without weight gain and PPAR[gamma] antagonists exert antiobesity action, a combination of these plants in diet could reduce obesity and the incidence of metabolic syndrome.

Author Affiliation:

Christian Doppler Laboratory for Receptor Biotechnology, Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria

Article History:

Received 7 November 2008; Revised 17 April 2009; Accepted 20 April 2009

Source Citation:Mueller, Monika, and Alois Jungbauer. "Culinary plants, herbs and spices - A rich source of PPAR[gamma] ligands." Food Chemistry 117.4 (Dec 15, 2009): 660(8). Academic OneFile. Gale. BROWARD COUNTY LIBRARY. 24 July 2009
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Gale Document Number:A203032055

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