Monday, May 21, 2012

9C Immune-mediated blood disorders

Blood check by Injection Girls
Blood check, a photo by Injection Girls on Flickr.
BAYRHO-D FULL DOSE Bayer Rx

[Rh.sub.0](D) immune globulin human 300mcg; for IM inj; solvent/detergent treated.

Indications: Preventing [Rh.sub.0](D) sensitization in nonsensitized [Rh.sub.0](D) negative or Du negative patients to the [Rh.sub.0](D) factor, following pregnancy or accidental transfusion.

Adults: Each vial or syringe (approx. 300mcg) prevents sensitization to a volume of up to 15mL of Rh positive red blood cells. Administer IM at 28 weeks of gestation, within 72 hours of an Rh incompatible delivery, miscarriage, abortion, or transfusion accident.

Children: Not recommended.

Also: BAYRHO-D MINI-DOSE Rx

[Rh.sub.0](D) immune globulin human 50mcg; for IM inj.

Indications: Prevention of [Rh.sub.0](D) sensitization following termination of pregnancies up to 12 weeks gestation.

Adults: Each syringe (approx. 50mcg) prevents sensitization to 2.5mL of Rh positive red blood cells. Give IM up to 12 weeks' gestation, within 3 hours of an Rh incompatible delivery, miscarriage, or abortion.

Children: Not recommended.

Contraindications: [Rh.sub.0](D) positive patients. Pregnancy (Cat.C).

Warnings/Precautions: Live vaccines. Have epinephrine available.

Adverse reactions: Local reactions.

How supplied: Full Dose (single-dose syringes and vials)--1, 10 Mini-Dose (single-dose syringes)--10

HYPERRHO S/D FULL DOSE Talecris Biotherapeutics Rx

Immune globulin. [Rh.sub.0](D) immune globulin human 1500 IU; per syringe; soln for IM inj; preservative-free; latex-free.

Indications: Prevention of isoimmunization in non-sensitized [Rh.sub.0](D) negative women during pregnancy and in appropriate obstetrical conditions, unless the fetus or father is known to be [Rh.sub.0](D) negative. Prevention of isoimmunization in [Rh.sub.0](D) negative individuals transfused with [Rh.sub.0](D) positive blood products.

Adults: See literature. Give IM only. Pregnancy (28 weeks gestation), postpartum prophylaxis (within 72 hours), obstetric complications, invasive procedures during pregnancy: 1500IU. Incompatible transfusions (within 72 hours): volume of red blood cells transfused divided by 15mL provides the number of syringes to be administered; if the dose is a fraction, round to next higher whole number of syringes.

Children: Not recommended.

Also: HYPERRHO S/D MINI-DOSE Rx

[Rh.sub.0](D) immune globulin human; 250 IU; per syringe; soln for IM inj.; preservative-free; latex-free.

Indications: Prevention of isoimmunization of [Rh.sub.0](D) negative women during spontaneous or induced abortion of [less than or equal to] 12 weeks' gestation when mother is not sensitized to [Rh.sub.0](D) antigen and father is not known to be [Rh.sub.0](D) negative.

Adults: Postabortion or miscarriage of up to 12 weeks gestation: 1 syringe IM within 3hrs of spontaneous or induced abortion or within 72hrs following termination of pregnancy.

Children: Not recommended.

Contraindications: Neonates.

Warnings/Precautions: Contains human plasma; monitor for possible infection transmission. IgA deficiency. Pregnancy (Cat.C).

Interactions: Avoid live vaccines within 3 months.

Adverse reactions: Local or infusion reactions.

Note: Report all infections suspected to be transmitted by HyperRHO S/D to (800) 520-2807.

How supplied: Full dose (Single-dose prefilled syringe)--1

Mini dose (Single-dose prefilled syringe)--10

RHOGAM Ortho Diagnostics Rx

[Rh.sub.0](D) immune globulin human 300mcg; for IM inj.

Indications: Preventing [Rh.sub.0](D) sensitization in nonsensitized [Rh.sub.0](D) negative or Du negative patients to the [Rh.sub.0](D) factor, following pregnancy or accidental transfusion.

Adults: Each vial or syringe (approx. 300mcg) prevents sensitization to a volume of up to 15mL of Rh positive red blood cells. Administer IM at 28 weeks of gestation, within 72 hours of an Rh incompatible delivery, miscarriage, abortion, or transfusion accident.

Children: See literature.

Also: MICRhoGAM Rx

[Rh.sub.0](D) immune globulin human 50mcg; for IM inj.

Indications: Prevention of [Rh.sub.0](D) sensitization following termination of pregnancies up to 12 weeks gestation.

Adults: Each syringe (approx. 50mcg) prevents sensitization to 2.5mL of Rh positive red blood cells.

Children: See literature.

Contraindications: [Rh.sub.0](D) positive patients.

Warnings/Precautions: Pregnancy (Cat.C).

Adverse reactions: Local reactions.

How supplied: Single-dose syringes--5, 25

RHOPHYLAC CSL Behring Rx

[Rh.sub.0](D) immune globulin human 1500 IU (300mcg)/2mL; syringe; for IV or IM inj; preservative- and latex-free; contains albumin (human); solvent/detergent treated.

Indications: Suppression of Rh isoimmunization in non-sensitized [Rh.sub.0](D) negative women during pregnancy and in appropriate obstetrical conditions, unless the fetus or father is known to be [Rh.sub.0](D) negative. Suppression of Rh isoimmunization in [Rh.sub.0](D) negative individuals transfused with [Rh.sub.0](D) positive blood products.

Adults: See literature. Pregnancy (28-30 weeks gestation), postpartum prevention (within 72 hours), obstetric complications, invasive procedures during pregnancy: 1500 IU (300mcg). Incompatible transfusions (within 72 hours): 100 IU (20mcg) per 2mL transfused blood or per 1mL erythrocyte concentrate.

Children: Not recommended.

Contraindications: [Rh.sub.0](D) positive patients. IgA deficiency.

Warnings/Precautions: Monitor patients 20 minutes after administration. Pregnancy (Cat.C).

Interactions: Do not give live vaccines within 3 months.

Adverse reactions: Local or infusion reactions, fever, chills, headache; see literature.

How supplied: Single-dose prefilled syringes--1, 10

WINRHO SDF Baxter Rx

[Rh.sub.0](D) immune globulin intravenous human 600IU (120mcg), 1500IU (300mcg), 2500IU (500mcg), 5000IU (1000mcg), 15000IU (3000mcg); per vial; lyophilized pwd or soln; for IV or IM inj after reconstitution; preservative-free.

Indications: Suppression of Rh isoimmunization in nonsensitized [Rh.sub.0](D) negative women in appropriate obstetrical conditions, unless the fetus or father is known to be [Rh.sub.0](D) negative. Suppression of Rh isoimmunization in [Rh.sub.0](D) negative females after accidental transfusion of [Rh.sub.0](D) positive blood products.

Adults: Pregnancy: 1500IU at 28 weeks gestation; if given early in pregnancy, repeat every 12 weeks. Post-delivery: 600IU as soon as possible (preferably within 72 hrs, up to 28 days) of an Rh incompatible delivery. Amniocentesis or other manipulation late in pregnancy (after 34 weeks gestation), abortion: 600IU as soon as possible (within 72 hrs). Chorionic villus sampling, amniocentesis (before 34 weeks gestation), threatened abortion: 1500IU as soon as possible, repeat every 12 weeks during pregnancy. Transfusion: IV route: 3000IU (600micrograms) every 8 hours; or IM route: 6000IU (1200micrograms) every 12 hours; for both: total dose based on exposure (see literature); give within 72 hours.

Children: See literature. Do not give to infant for maternal Rh incompatability.

Contraindications: [Rh.sub.0](D) positive patients. IgA deficiency. Allergy to blood products. Treatment of immune globulin deficiency syndromes.

Warnings/Precautions: [Rh.sub.0](D) negative patients who are Rh immunized. Thrombocytopenia. Pregnancy (Cat.C).

Interactions: Do not give live vaccines within 3 months.

Adverse reactions: Local or infusion reactions, fever; see literature.

Note: Report all infections suspected to be transmitted by WinRho SDF to (800) 423-2090.

How supplied: Single-dose vials (pwd) 600IU, 1500IU, 5000IU--1 (w. diluent) Single-dose vials (soln) 600IU, 1500IU, 2500IU, 5000IU, 15000IU--1

Source Citation
"9C Immune-mediated blood disorders." MPR [Hematology and Oncology Edition] Summer 2012: 75+. Health Reference Center Academic. Web. 21 May 2012.
Document URL
http://go.galegroup.com/ps/i.do?id=GALE%7CA288537205&v=2.1&u=22054_acld&it=r&p=HRCA&sw=w

Gale Document Number: GALE|A288537205

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